Saturday, February 28, 2015

Regulus Therapeutics Inc (NASDAQ: RGLS)

Regulus Therapeutics Inc., a biopharmaceutical company, focuses on the discovery and development of drugs that target microRNAs for the treatment of various diseases in the United States. The company uses its microRNA product platform to develop anti-miRs, which is chemically modified and single-stranded oligonucleotide. The company has strategic collaboration with Biogen Idec MA Inc. for the evaluation of the use of microRNA signatures as a biomarker for human patients with multiple sclerosis; AstraZeneca AB to discover and develop microRNA therapeutics for cardiovascular diseases, metabolic diseases, and oncology; and GlaxoSmithKline plc to discover and develop microRNA therapeutics for immuno-inflammatory diseases. It also has strategic collaboration with Sanofi for the discovery and development of microRNA therapeutics comprising miR-21 pre-clinical fibrosis program for the treatment of alport syndrome and preclinical program for oncology indications.
Take a look at the 1-year chart of Regulus (Nasdaq: RGLS) below with my added notations:
1-year chart of Regulus (Nasdaq: RGLS)
RGLS had steadily went nowhere from April until mid-October. Then, the stock jumped massively on route to hitting a new high just above $25. Since that time, the stock has created an obvious resistance at $20 (green). A break above that $20 level should mean higher prices for the stock.

The Tale of the Tape: RGLS has a key level of resistance at $20. A long trade could be entered on a break through that level. However, if you are bearish on the stock, a short trade could be made on any rallies up to $20.
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Is Rob McEwen Looking To Buy?

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S&P 500 Snapshot: Biggest Monthly Gain Since October 2011

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The markets had much to consider this week, most notably Fed Chair Yellen's semi-annual congressional testimony on Tuesday and Thursday and today's updates on Consumer Sentiment and GDP. The S&P 500 showed relatively little reaction to any of this week's economic events, trading within a microscopic 0.79% range from its intraday low on Monday to its intraday high on Wednesday (which was also its record high). Today's -0.30% closing loss trimmed the February monthly gain to a whopping 5.49%, the biggest monthly gain since October of 2011, 40 months ago, when the index rose 10.77%.
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Is This The Greatest Threat To The World?

Is This The Greatest Threat To The World? / February 27, 2015
With the Dow near 18,200, crude oil still below $50 and gold on the move, today a legend in the business sent King World News a powerful piece warning about one of the greatest threats to the world that would violently impact every major market and individual around the globe.
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Chicago PMI Crashes to 5 1/2 Year Low: Production, New Orders, Backlogs Suffer Double Digit Declines / Mike “Mish” Shedlock  / February 27, 2015
Fourth quarter GDP was revised lower today to 2.2 percent from 2.6 percent previously estimated.
Looking ahead, I think we are going to see some shocking downward estimates in the months to come. Meanwhile, a shocking PMI report came out today.
Chicago PMI Crashes to 5 1/2 Year Low
ISM Chicago reports Chicago Business Barometer At 5½-Year Low
The Chicago Business Barometer plunged 13.6 points to 45.8 in February, the lowest level since July 2009 and the first time in contraction since April 2013. The sharp fall in business activity in February came as Production, New Orders, Order Backlogs and Employment all suffered double digit losses, leaving them below the 50 level which separates contraction from expansion.
New Orders suffered the largest monthly decline on record, leaving them at the lowest since June 2009. Lower order intake and output levels led to a double digit decline in Employment which last month increased markedly to a 14-month high.
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Outlook for December 15 Corn Futures

As the winter moves on towards Spring and U.S. farmers begin to gear up for the 2015 planting season, my sense is there is very little downside price risk to new crop corn futures over the next couple of months.  Over the past six weeks December 2015 corn futures have traded in a sideways pattern between $4.00 and $4.20 per bu.  This is the lowest level for December futures during this period since 2010.  Granted there are valid reasons for prices to be this low relative to recent years.  Following last year's record yield and record production, U.S. corn supplies are currently projected to exceed 1.8 billion bu. by the time new crop supplies are available this fall, a nine year high. In addition, global stocks are expected to build to nearly 190 million metric tons, which is a 15 year high. (more)

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